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10:03
Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
[Posttraumatic meningitis: incidence, bacteriology, and outcomes].
H Kallel1, H Chelly, M Ghorbel
1Service de Réanimation Médicale, CHU Habib-Bourguiba, route El-Aïn, km 1, 3029 Sfax, Tunisie. Kallelhat@yahoo.fr
Neuro-Chirurgie
|December 23, 2006
Summary
Antibiotic prophylaxis in head trauma patients may promote multidrug-resistant bacteria, increasing post-traumatic meningitis (PTM) risk. Key mortality predictors include Glasgow Coma Scale score and specific bacterial agents.
Area of Science:
- Neuroscience
- Infectious Diseases
- Critical Care Medicine
Context:
- Post-traumatic meningitis (PTM) is a serious complication following head injuries.
- Understanding the incidence, causative organisms, and mortality factors of PTM is crucial for effective management.
Purpose:
- To investigate the incidence, responsible organisms, and mortality predictors of post-traumatic meningitis (PTM).
Summary:
- A retrospective study over seven years identified 38 PTM cases (0.96% of head injury admissions).
- Multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Streptococcus pneumoniae were common pathogens.
- Predictors of 14-day mortality included Glasgow Coma Scale (GCS) score, absence of nuchal rigidity, cerebrospinal fluid (CSF) protein, CSF/blood glucose ratio, and S. pneumoniae infection.
Impact:
- Findings suggest avoiding antibiotic prophylaxis in head trauma to prevent multidrug-resistant bacteria emergence.
- Identified prognostic factors (GCS, CSF protein, CSF/blood glucose ratio, S. pneumoniae) can guide clinical decision-making and patient care.
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