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Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Updated: Jul 11, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

The Connectivity Map: a new tool for biomedical research.

¹Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA. justin@broad.mit.edu

Nature Reviews. Cancer

|December 23, 2006

Summary

Biomedical research aims to link human diseases, genes, and drugs. The Connectivity Map project explored systematizing this process, creating a centralized resource for drug discovery and disease research.

Area of Science:

Biomedical research
Genomics
Pharmacology

Background:

Connecting human diseases with causative genes and effective drugs is a major challenge in biomedical research.
Current methods often involve laborious screening of genetic or chemical libraries, hindering efficient discovery.

Approach:

The Connectivity Map project aimed to systematize and centralize parts of the screening process.
It explored the potential of an 'internet search engine'-like approach for generating hypotheses and finding drug-disease connections.

Key Points:

Investigating the systematic connection between gene expression profiles and drug actions.
Developing a centralized database for querying relationships between diseases, genes, and potential therapeutics.
Facilitating hypothesis generation for drug discovery through computational methods.

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Conclusions:

The Connectivity Map project sought to streamline the identification of disease-gene-drug relationships.
It proposed a novel, searchable platform to accelerate biomedical research and drug development.