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Updated: Jul 18, 2026

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
Published on: September 11, 2020
[Neonatal meningitis caused by atypical Streptococcus pneumoniae: case report and review]
Verónica Silva B1, Felipe Castillo F, Paula O Reilly F
1Servicio de Neonatología, Hospital Parroquial San Bernardo, Santiago, Chile. vsblanch@gmail.com
Abstract:
Streptococcus pneumoniae is a rarely recognized cause of neonatal sepsis and/or meningitis, but it is associated with substantial morbidity and mortality. Traditionally, S. pneumoniae is identified in the laboratory by demonstrating susceptibility to optochin. However, the emergence of optochin-resistant organisms makes definite identification difficult when only phenotypic tests are taken as markers. We present the case of a severe early-onset neonatal meningitis due to an atypical strain of S. pneumoniae. Laboratory methods utilized to certify this species diagnosis are discussed.
Insights
Streptococcus pneumoniae rarely causes neonatal sepsis and meningitis, but poses significant risks. Identifying optochin-resistant strains requires advanced laboratory methods beyond traditional phenotypic tests.
Area of Science:
- Neonatal infectious diseases
- Bacterial meningitis
- Microbiology
Background:
- Streptococcus pneumoniae is an infrequent but serious cause of neonatal sepsis and meningitis.
- The condition is linked to considerable illness and death in newborns.
- Traditional identification relies on optochin susceptibility, a method challenged by resistant strains.
Observation:
- A case of severe early-onset neonatal meningitis caused by an atypical Streptococcus pneumoniae strain is presented.
- This case highlights diagnostic challenges posed by optochin-resistant S. pneumoniae.
- The study discusses laboratory techniques used for accurate species identification.
Findings:
- Atypical Streptococcus pneumoniae strains can cause severe neonatal meningitis.
- Optochin resistance in S. pneumoniae complicates laboratory diagnosis.
- Advanced laboratory methods are crucial for confirming the species in such cases.
Implications:
- Neonatal meningitis due to S. pneumoniae requires careful diagnostic consideration.
- The emergence of optochin resistance necessitates updated diagnostic protocols.
- Accurate identification of S. pneumoniae is vital for appropriate neonatal care and management.
Related Concept Videos
Bacterial Meningitis I: Introduction
Bacterial Meningitis II: Pathophysiology
Atypical Pneumonia
Bacterial Meningitis
Viral Meningitis
Pneumonia I: Introduction
