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Updated: Jul 18, 2026
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Transient severe metastatic calcification in acute renal failure
Daniel Landau1, Hanna Krymko, Hanna Shalev
1Department of Pediatrics A, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel. ldaniel@bgu.ac.il
Pediatric Nephrology (Berlin, Germany)
|December 23, 2006
Summary
Metastatic calcification, a rare complication of acute renal failure in infants, was successfully treated with sodium thiosulfate. This case highlights a novel therapeutic approach for pediatric renal disease complications.
Area of Science:
- Pediatric Nephrology
- Radiology
- Medical Imaging
Background:
- Metastatic calcification is a known complication of chronic end-stage renal disease.
- Acute renal failure (ARF) in infants is less commonly associated with metastatic calcification.
Observation:
- A 10-month-old boy presented with acute renal failure and a painful, swollen arm.
- Imaging studies showed extensive calcification and technetium-99 methylene diphosphonate (99Tc-MDP) uptake in the humerus and axilla.
Findings:
- The patient received calcium and vitamin D restriction.
- Intravenous sodium thiosulfate administration led to complete resolution of symptoms.
- Radiographic and scintigraphic abnormalities normalized after treatment.
Implications:
- This case demonstrates the first reported instance of metastatic calcification in an infant with acute renal failure.
- Sodium thiosulfate is a potential therapeutic agent for managing metastatic calcification in pediatric patients.
- Early recognition and intervention are crucial for managing this rare complication of renal failure.
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