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Synthesis and biochemical studies of dithioate DNA
M H Caruthers1, G Beaton, L Cummins
1Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.
Ciba Foundation Symposium
|January 1, 1991
Abstract:
Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in HeLa cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.