Pediatric end-stage renal disease: single center analysis

Area of Science:

• Nephrology
• Pediatrics
• Public Health

Background:

• Limited data exists on pediatric end-stage renal disease (ESRD) in Jordan due to a lack of national registry systems.
• Understanding the demographics and etiology of pediatric ESRD is essential for developing targeted interventions and improving renal replacement therapy.

Purpose of the Study:

• To define the etiology, prevalence, incidence, and demographic features of pediatric ESRD and renal replacement therapy at King Hussein Medical Center.
• To identify specific characteristics of pediatric ESRD in Jordan.

Main Methods:

• A retrospective analysis was conducted on pediatric patients who entered the chronic dialysis program or received pre-emptive transplants between January 2001 and December 2005.
• Data collected included patient demographics, cause of ESRD, and renal replacement therapy modality.

Main Results:

• The study included 42 pediatric patients with a mean age of 11.10 years at dialysis initiation; 45.2% were males.
• The prevalence of pediatric ESRD in Jordan was 14.5 per million population.
• Acquired glomerulopathy (31%), oxalosis (16.7%), and neurogenic bladder (14.3%) were the most common causes of ESRD. Hemodialysis was the primary therapy (95.2%).
• One and three-year graft survival rates after transplantation were 87.5% and 72.5%, respectively.

Conclusions:

• Pediatric ESRD in Jordan presents with distinctive features, notably a high incidence of oxalosis and neurogenic bladder.
• The establishment of a national registry for pediatric ESRD is recommended to guide renal replacement therapy choices and improve patient management.
• Further research is needed to understand the long-term outcomes and specific management strategies for pediatric ESRD in the region.