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Pediatric end-stage renal disease: single center analysis
1Department of Pediatric Nephrology, King Hussein Medical Center, Amman, Jordan.
Summary
Pediatric end-stage renal disease (ESRD) in Jordan shows unique causes like oxalosis and neurogenic bladder. Establishing a national registry is crucial for effective pediatric renal replacement therapy and improved patient outcomes.
Area of Science:
- Nephrology
- Pediatrics
- Public Health
Background:
- Limited data exists on pediatric end-stage renal disease (ESRD) in Jordan due to a lack of national registry systems.
- Understanding the demographics and etiology of pediatric ESRD is essential for developing targeted interventions and improving renal replacement therapy.
Purpose of the Study:
- To define the etiology, prevalence, incidence, and demographic features of pediatric ESRD and renal replacement therapy at King Hussein Medical Center.
- To identify specific characteristics of pediatric ESRD in Jordan.
Main Methods:
- A retrospective analysis was conducted on pediatric patients who entered the chronic dialysis program or received pre-emptive transplants between January 2001 and December 2005.
- Data collected included patient demographics, cause of ESRD, and renal replacement therapy modality.
Main Results:
- The study included 42 pediatric patients with a mean age of 11.10 years at dialysis initiation; 45.2% were males.
- The prevalence of pediatric ESRD in Jordan was 14.5 per million population.
- Acquired glomerulopathy (31%), oxalosis (16.7%), and neurogenic bladder (14.3%) were the most common causes of ESRD. Hemodialysis was the primary therapy (95.2%).
- One and three-year graft survival rates after transplantation were 87.5% and 72.5%, respectively.
Conclusions:
- Pediatric ESRD in Jordan presents with distinctive features, notably a high incidence of oxalosis and neurogenic bladder.
- The establishment of a national registry for pediatric ESRD is recommended to guide renal replacement therapy choices and improve patient management.
- Further research is needed to understand the long-term outcomes and specific management strategies for pediatric ESRD in the region.
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