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A Swine Model of Neonatal Asphyxia
Published on: October 11, 2011
Cord blood IGF-1 and IGFBP-3 levels in asphyxiated term newborns
Ener Cagri Dinleyici1, Neslihan Tekin, Omer Colak
1Department of Pediatric Neurology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey. timboothtr@yahoo.com
Insights
Perinatal asphyxia in newborns is linked to lower levels of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) in cord blood. These findings correlate with markers of hypoxia and acidosis at birth.
Area of Science:
- Neonatal research
- Pediatric endocrinology
- Perinatal medicine
Background:
- Perinatal asphyxia presents significant challenges in newborn care.
- Insulin-like growth factors (IGF) and their binding proteins (IGFBP) are implicated in cellular injury and recovery.
- Previous studies suggest altered IGF and IGFBP expression in experimental models of injury.
Purpose of the Study:
- To investigate the relationship between cord blood levels of IGF-1 and IGFBP-3 and perinatal asphyxia.
- To assess the correlation of these growth factors with clinical and biochemical markers of asphyxia.
Main Methods:
- Umbilical cord blood samples were collected from 18 term-newborns with perinatal asphyxia and 12 healthy controls.
- Levels of IGF-1 and IGFBP-3 were measured in cord blood.
- Correlations were analyzed with Apgar scores and umbilical artery blood gas parameters (pH, pCO2, pO2, base excess, HCO3, ctCO2, SO2) and lactate.
Main Results:
- Asphyxiated newborns exhibited significantly lower cord blood IGF-1 and IGFBP-3 levels compared to controls.
- Cord blood IGF-1 positively correlated with birth weight, Apgar scores, and arterial pH parameters (pH, ABE, HCO3, SO2).
- Cord blood IGFBP-3 showed positive correlations with Apgar scores, pH parameters (pH, pCO2, ABE, HCO3, SO2), and negative correlations with cord CO2 and lactate.
Conclusions:
- Reduced cord blood IGF-1 and IGFBP-3 levels are strongly associated with perinatal asphyxia.
- Hypoxia and acidosis at birth are linked to diminished IGF-1 and IGFBP-3 expression.
- These findings highlight the potential role of IGF-1 and IGFBP-3 as biomarkers in neonatal asphyxia.
Objective:
Determination and pathogenesis of perinatal asphyxia is still an important problem. During the asphyxial insult and recovery phase, alteration of the growth factors has been demonstrated and there is evidence that expression of insulin-like growth factors (IGF) and their insulin-like growth factor binding proteins (IGFBP) in injured sites in experimental studies. Aim of this study was to evaluate relationship between serum IGF-1, IGFBP-3 levels and perinatal asphyxia.
Patients And Methods:
18 term-newborn who defined as perinatal asphyxia and 12 term-healthy newborn were enrolled. Umbilical cord IGF-1 and IGFBP-3 levels were detected and searched correlation with apgar scores and umbilical artery gas analysis as pH, pC02, pO2, base excess, HCO3, ctO2, SO2 and lactate levels.
Results:
Cord blood IGF-1 and IGFBP-3 levels for asphyxiated newborns were lower than normal group (27.8+/-2.6 ng/ml, 55.1+/-2.8 ng/ml respectively, p<0.01 for IGF-1; 1107.7+/-320.4, 1682.5+/-364.1, p<0.001 for IGFBP-3). Cord blood IGF-1 levels were positively correlated with birth weight; first and 5th minute Apgar score, cord blood arterial pH, ABE, HCO3, SO2 levels. Cord blood IGFBP-3 levels were positively correlated with first and 5th minutes Apgar scores, cord blood arterial pH, pCO2, ABE, HCO3, sO2, and also negatively correlated with cord CO2 and cord lactate levels.
Conclusion:
Our study demonstrates that exposure to hypoxia and acidosis at birth strongly correlated with a fall in IGF-1 and IGFBP-3 levels in cord blood.
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