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Related Experiment Videos

Selfprotective smart orthopedic implants.

Javad Parvizi1, Valentin Antoci, Noreen J Hickok

  • 1Thomas Jefferson University, Rothman Institute of Orthopedics, 925 Chestnut Street, Philadelphia, PA 19107, USA. parvj@aol.com

Expert Review of Medical Devices
|December 26, 2006
PubMed
Summary
This summary is machine-generated.

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Frontiers in cell and developmental biology·2022

New orthopedic implant designs focus on cellular interactions and smart devices to combat complications like infection. Tethering antibiotics to implant surfaces shows promise in preventing periprosthetic infections.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Nanotechnology

Background:

  • Traditional orthopedic implants relied on basic biomaterials.
  • Implant complications such as loosening and infection remain significant challenges.
  • Advancements in cellular-molecular interactions and nanoscale chemistry are revolutionizing implant design.

Purpose of the Study:

  • To review current advances in orthopedic implant design.
  • To highlight new strategies for addressing implant complications, specifically infection.
  • To discuss the potential of next-generation 'smart' implants.

Main Methods:

  • Review of current literature on orthopedic implant design and biomaterials.
  • Analysis of emerging technologies in cellular-molecular interactions and nanoscale chemistry.

Related Experiment Videos

  • Discussion of local drug delivery systems and tethered bioactive molecules.

    • Main Results:

    • Shift from biomaterial-centric to cellular-molecular and nanoscale approaches in implant design.
    • Development of local delivery systems for infection control.
    • Emergence of self-protective 'smart' orthopedic devices.
    • Potential of covalently bonded antibiotics or biofactors to prevent periprosthetic infection.

    Conclusions:

    • Next-generation orthopedic implants utilizing advanced surface modifications and smart technologies hold significant promise.
    • Tethering active molecules like antibiotics to implant surfaces could revolutionize infection prevention.
    • This technological shift has the potential to eliminate periprosthetic infection, a major clinical problem.