Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Arrayed identification of DNA signatures.

Max Käller1, Joakim Lundeberg, Afshin Ahmadian

  • 1AlbaNova University Center, School of Biotechnology, Department of Gene Technology, Royal Institute of Technology, Roslagstullsbacken 21, SE-106 91 Stockholm, Sweden. max.kaller@stanford.edu

Expert Review of Molecular Diagnostics
|December 26, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resolving the Haplotype Complexity of Colorectal Cancer Genomes with Droplet Barcode Sequencing.

Life (Basel, Switzerland)·2026
Same author

Publisher Correction: TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration.

Nature neuroscience·2026
Same author

Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve.

Nature communications·2026
Same author

Single-cell spatial multi-omics molecular pathology enabled by SuperFocus.

bioRxiv : the preprint server for biology·2026
Same author

Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy-Naïve Localized Prostate Cancer.

Cancer research·2026
Same author

Exploration of immune phenotypes in self-sampling citizens.

iScience·2026
Same journal

Bacterial respiratory infections: advances in diagnostic strategies.

Expert review of molecular diagnostics·2026
Same journal

Artificial intelligence in molecular diagnostics for pandemic preparedness.

Expert review of molecular diagnostics·2026
Same journal

Navigating PD-L1 testing in immuno-oncology: analytical robustness, clinical validation, and the role of the VENTANA SP263 assay.

Expert review of molecular diagnostics·2026
Same journal

Extracellular vesicles as diagnostic and prognostic biomarkers in non-small cell lung cancer.

Expert review of molecular diagnostics·2026
Same journal

Explainable epigenetic aging clocks: an overview of existing AI models and approaches.

Expert review of molecular diagnostics·2026
Same journal

Neuro-axonal injury biomarker serum neurofilament light chain is associated with osteoarthritis: a dual-cohort study from NHANES and UK Biobank.

Expert review of molecular diagnostics·2026
See all related articles

Advancements in DNA sequencing and genotyping technologies offer cost-effective solutions for large-scale genetic analysis. However, reliable methods for routine human genome re-sequencing for personalized medicine are still under development.

Area of Science:

  • Molecular Biology
  • Genomics
  • Biotechnology

Background:

  • Several initiatives combine molecular biology techniques with parallel detection for DNA sequencing and genotyping.
  • Existing systems like Illumina's Infinium and Affymetrix GeneChips enable whole-genome scoring of variable positions.
  • Directed candidate-gene approaches offer cost-effectiveness for large sample capacities.

Purpose of the Study:

  • To review recent advancements in DNA sequencing and genotyping technologies.
  • To assess the potential of new platforms as alternatives to conventional genotyping.
  • To highlight the need for reliable human genome re-sequencing methods for personalized medicine.

Main Methods:

  • Review of existing and emerging DNA sequencing and genotyping technologies.

Related Experiment Videos

  • Comparison of different approaches based on cost-effectiveness, throughput, and sample capacity.
  • Discussion of sequencing-by-synthesis and ligation-based sequencing initiatives.

    • Main Results:

    • Platforms like 454 Life Sciences and Solexa offer promising alternatives to conventional genotyping.
    • Novel ideas are emerging for fast and cost-effective whole genome sequencing.
    • Current technologies are suitable for whole-genome scoring and candidate-gene approaches.

    Conclusions:

    • Significant progress has been made in DNA sequencing and genotyping technologies.
    • New sequencing platforms show great potential for genetic analysis.
    • Development of reliable routine human genome re-sequencing methods is crucial for personalized medicine.