Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 10, 2026

A Microfluidic Platform for Longitudinal Imaging in Caenorhabditis elegans
09:00

A Microfluidic Platform for Longitudinal Imaging in Caenorhabditis elegans

Published on: May 2, 2018

Reproduction and longevity: secrets revealed by C. elegans.

Arnab Mukhopadhyay1, Heidi A Tissenbaum

  • 1Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School 364 Plantation Street, Worcester, MA 01605, USA.

Trends in Cell Biology
|December 26, 2006
PubMed
Summary

Reproduction may shorten lifespan by diverting resources from body maintenance. Studies in Caenorhabditis elegans reveal conserved mechanisms linking reproductive signaling to longevity, offering insights into this fundamental biological tradeoff.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DAF-16/FOXO maintains genome integrity following genotoxic stress.

bioRxiv : the preprint server for biology·2025
Same author

Localized Hydrogel-Mediated Docetaxel-Carboplatin Combination Chemotherapy Targets Ganglioside Metabolism to Mitigate Tumor Progression.

ACS pharmacology & translational science·2025
Same author

mTORC2 disruption reprograms nutrient-driven behavioral adaptations in <i>C. elegans</i>.

microPublication biology·2025
Same author

The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.

PLoS biology·2025
Same author

RICTOR regulates an interspecies crosstalk that influences longevity through a novel methionine cycle-mitophagy axis.

bioRxiv : the preprint server for biology·2025
Same author

Kinome-wide RNAi screening in <i>Caenorhabditis elegans</i> reveals new modulators of insulin signaling and longevity.

Journal of biosciences·2025

Area of Science:

  • Evolutionary biology
  • Genetics
  • Aging research

Background:

  • Reproduction is often associated with a trade-off in longevity.
  • This suggests a conserved evolutionary mechanism linking reproductive effort to somatic maintenance and lifespan.
  • The mechanistic details of this regulation remain largely unexplored.

Purpose of the Study:

  • To explore the relationship between reproduction and longevity.
  • To discuss recent advances in understanding how reproductive signaling regulates lifespan.
  • To focus on mechanistic insights gained from studies in Caenorhabditis elegans.

Main Methods:

  • Review of existing literature on reproduction and longevity.
  • Analysis of studies utilizing the model organism Caenorhabditis elegans.

More Related Videos

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

Related Experiment Videos

Last Updated: Jul 10, 2026

A Microfluidic Platform for Longitudinal Imaging in Caenorhabditis elegans
09:00

A Microfluidic Platform for Longitudinal Imaging in Caenorhabditis elegans

Published on: May 2, 2018

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

  • Focus on experimental manipulations and natural variations in fecundity and lifespan.

    • Main Results:

    • Evidence suggests a conserved mechanism where reproduction incurs a cost to somatic maintenance, thereby reducing longevity.
    • Reproductive signaling pathways play a key role in mediating this trade-off.
    • Studies in Caenorhabditis elegans provide detailed insights into these regulatory processes.

    Conclusions:

    • Reproduction and longevity are intricately linked through conserved biological mechanisms.
    • Understanding reproductive signaling is crucial for deciphering lifespan regulation.
    • Caenorhabditis elegans serves as a valuable model for investigating the interplay between reproduction and aging.