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The effect of the 5-HT1A receptor agonist, 8-OH-DPAT, on motion-induced emesis in Suncus murinus

Farideh A Javid1, Robert J Naylor

  • 1The School of Pharmacy, University of Bradford, Bradford BD7 1DP, United Kingdom. fajavid1@brad.ac.uk

Pharmacology, Biochemistry, and Behavior
|December 26, 2006
PubMed

Insights

The study found that the 5-HT(1A) receptor agonist 8-OH-DPAT reduces motion sickness in Suncus murinus. However, blocking various serotonin receptors did not affect this anti-motion sickness action, suggesting 5-HT(1A) receptors are not involved.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gastroenterology

Background:

  • Motion sickness is a common condition with significant impact.
  • Serotonin (5-HT) receptors are implicated in various physiological processes, including emesis.
  • The specific role of 5-HT receptor subtypes in mediating anti-motion sickness effects requires further elucidation.

Purpose of the Study:

  • To investigate the involvement of 5-HT(1A) receptors in the anti-emetic effects of 8-OH-DPAT in a motion sickness model.
  • To determine if other serotonin receptor subtypes (5-HT(2), 5-HT(3), 5-HT(4), 5-HT(7)) play a role in this mechanism.

Main Methods:

  • Utilized Suncus murinus as an animal model for motion sickness.
  • Administered 8-OH-DPAT, a 5-HT(1A) receptor agonist, to induce an anti-motion sickness effect.
  • Tested the effects of various receptor antagonists (methysergide, WAY-100635, SB269970A, ondansetron, GR13808) alone and in combination with 8-OH-DPAT.

Main Results:

  • 8-OH-DPAT significantly attenuated motion-induced emesis and increased the latency to the first emetic episode.
  • Pre-treatment with antagonists for 5-HT(1A), 5-HT(7), 5-HT(3), and 5-HT(4) receptors did not alter the inhibitory effect of 8-OH-DPAT.
  • None of the tested antagonists alone affected motion sickness severity.

Conclusions:

  • The inhibitory action of 8-OH-DPAT on motion sickness in Suncus murinus is not mediated by 5-HT(1A) receptors.
  • The study suggests that 5-HT(1A), 5-HT(2), 5-HT(3), 5-HT(4), and 5-HT(7) receptors are unlikely to be involved in the anti-emetic effects observed with 8-OH-DPAT.

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