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Enhanced resistance against Listeria monocytogenes achieved by pretreatment with granulocyte colony-stimulating
N Shinomiya1, S Tsuru, Y Katsura
1Department of Microbiology, National Defense Medical College, Saitama, Japan.
Infection and Immunity
|December 1, 1991
Abstract:
Phagocytosis, H2O2 production, Mac-1 expression, and in vivo elimination of Listeria monocytogenes were enhanced in granulocyte colony-stimulating factor (G-CSF)-treated mice. Transfer of polymorphonuclear leukocytes prolonged survival of mice infected with a lethal dose of L. monocytogenes. G-CSF augments the functions of polymorphonuclear leukocytes and thus plays a role in protection.