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Updated: Jul 18, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Symmetry-based recoupling of proton chemical shift anisotropies in ultrahigh-field solid-state NMR
Darren H Brouwer1, John A Ripmeester
1Steacie Institute for Molecular Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ont., Canada K1A 0R6. Darren.Brouwer@nrc.ca
Abstract:
A two-dimensional NMR experiment for estimating proton chemical shift anisotropies (CSAs) in solid powders under magic-angle spinning conditions is demonstrated in which 1H CSAs are reintroduced with a symmetry-based recoupling sequence while the individual proton sites are resolved according to their isotropic chemical shifts by magic-angle spinning (MAS) or combined rotation and multiple pulse (CRAMPS) homonuclear decoupling. The experiments where carried out on an ultrahigh-field solid-state NMR instrument (900 MHz 1H frequency) which leads to increased resolution and reliability of the measured 1H CSAs. The experiment is expected to be important for investigating hydrogen bonding in solids.
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