Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Cells and Tissue

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term skeletal stability in the treatment of mandibular prognathism with a physiological positioning strategy.

The British journal of oral & maxillofacial surgery·2019

Same author

Issues with the surgical treatment of antiresorptive agent-related osteonecrosis of the jaws.

Oral diseases·2018

Same author

Clinical application of autogenous partially demineralized dentin matrix prepared immediately after extraction for alveolar bone regeneration in implant dentistry: a pilot study.

International journal of oral and maxillofacial surgery·2017

Same author

Potential application of tissue engineering for the reconstruction of facial bones.

Oral diseases·2016

Same author

Administration of teriparatide improves the symptoms of advanced bisphosphonate-related osteonecrosis of the jaw: preliminary findings.

International journal of oral and maxillofacial surgery·2015

Same author

A clinicopathological study of perineural invasion and vascular invasion in oral tongue squamous cell carcinoma.

International journal of oral and maxillofacial surgery·2015

Search research articles

Related Experiment Video

Updated: May 22, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Effective bone engineering with periosteum-derived cells.

H Agata¹, I Asahina, Y Yamazaki

¹Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Journal of Dental Research

|December 26, 2006

Summary

This summary is machine-generated.

Periosteum-derived cells can regenerate bone effectively. Pre-treatment with bFGF enhances their osteogenic potential, making them a promising alternative to bone marrow stromal cells for bone tissue engineering.

More Related Videos

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Related Experiment Videos

Last Updated: May 22, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Area of Science:

Regenerative Medicine
Biomaterials Science
Orthopedic Surgery

Background:

Bone tissue engineering aims to regenerate bone defects using cellular therapies.
Bone marrow stromal cells are commonly used, but alternatives are sought.
Periosteum is a potential cell source, but its osteogenic capacity requires clarification.

Purpose of the Study:

Compare osteogenic potential of periosteum-derived cells versus bone marrow stromal cells.
Identify optimal osteoinductive conditions for periosteum-derived cells.
Evaluate the efficacy of periosteum-derived cells in bone regeneration.

Main Methods:

Induction of both cell types towards osteoblast differentiation using bFGF and BMP-2.
Assessment of cell proliferation and osteogenic marker expression.
In vivo transplantation studies to evaluate new bone formation.

Main Results:

Periosteal cells exhibited faster proliferation than marrow stromal cells.
Bone marrow stromal cells showed higher basal osteogenic potential.
Pre-treatment with bFGF significantly enhanced periosteal cell sensitivity to BMP-2 and osteogenesis.
Transplanted periosteal cells, pre-treated with bFGF and BMP-2, formed more new bone than marrow stromal cells.

Conclusions:

Combined bFGF and BMP-2 treatment significantly boosts the osteogenic capacity of periosteum-derived cells.
Periosteum is a viable and potentially superior cell source for bone regeneration compared to bone marrow stromal cells under optimized conditions.
This strategy offers a promising approach for bone augmentation and defect repair.