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Related Experiment Videos

Unusual dendritic keratitis.

Nikhil S Gokhale1, Alpa J Dherai, Haresh Desai

  • 1Gokhale Eye Hospital and Eyebank, Anant Building, Gokhale Road, Dadar West, Mumbai-400 028, India. gokhlay@vsnl.com

Indian Journal of Ophthalmology
|December 27, 2006
PubMed
Summary
This summary is machine-generated.

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Tyrosinemia, a rare metabolic disorder, can cause bilateral pseudo-dendritic keratitis in infants. Early diagnosis and dietary changes can reverse these ocular and skin manifestations.

Area of Science:

  • Biochemistry
  • Ophthalmology
  • Genetics

Background:

  • Tyrosinemia is a rare inherited metabolic disorder.
  • Ocular manifestations can be the first sign of tyrosinemia.
  • Prompt diagnosis is crucial for effective management.

Observation:

  • Bilateral pseudo-dendritic keratitis in infants can indicate tyrosinemia.
  • This condition may present with palmoplantar keratosis.
  • Non-responsive dendritic keratitis in children warrants investigation for tyrosinemia.

Findings:

  • Elevated serum tyrosine levels are indicative of tyrosinemia.
  • Dietary modifications can lead to complete reversal of tyrosinemia symptoms.
  • Ocular and cutaneous lesions associated with tyrosinemia are treatable.

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Implications:

  • Suspecting tyrosinemia in pediatric cases of non-responsive keratitis is vital.
  • Measuring serum tyrosine levels aids in early diagnosis.
  • Timely intervention can prevent long-term complications of tyrosinemia.