Related Experiment Video

Updated: Jul 18, 2026

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence
09:21

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence

Published on: October 11, 2018

Massive intravascular hemolysis in a patient infected by a Clostridium perfringens

Shoichiro Ohtani1, Naomi Watanabe, Masashi Kawata

  • 1Department of Surgery, Tamashima Central Hospital, Kurashiki, Okayama 713-8122, Japan.

Acta Medica Okayama
|December 27, 2006
PubMed

Insights

Clostridium perfringens infection is a rare cause of massive intravascular hemolysis. Prompt treatment is crucial for survival in patients with this severe septicemia.

Area of Science:

  • Infectious Diseases
  • Hematology

Background:

  • Clostridium perfringens is a rare but serious cause of massive intravascular hemolysis.
  • Early recognition and treatment are critical for patient survival.

Observation:

  • A 78-year-old diabetic male presented with fatigue, dark red urine, and vomiting.
  • Massive hemolysis and a large liver abscess were identified.
  • The patient rapidly deteriorated and died within hours of admission.

Findings:

  • Clostridium perfringens was identified in blood and liver abscess samples.
  • The patient's death was attributed to acute massive intravascular hemolysis secondary to C. perfringens septicemia.

Implications:

  • Highlights the importance of considering C. perfringens in cases of unexplained massive hemolysis.
  • Emphasizes the need for rapid diagnosis and aggressive management of C. perfringens infections.
  • Underscores the potentially fatal outcome of delayed treatment for this condition.

More Related Videos

Enrichment and Detection of Clostridium perfringens Toxinotypes in Retail Food Samples08:00

Enrichment and Detection of Clostridium perfringens Toxinotypes in Retail Food Samples

Published on: October 18, 2019

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage09:41

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Published on: July 3, 2014

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...