Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Widening the protein crystallization bottleneck.

Allison Doerr

    Nature Methods
    |December 27, 2006
    PubMed
    Summary
    This summary is machine-generated.

    Simple methods may increase the number of proteins that can be crystallized. These techniques aim to improve protein crystallization for broader research applications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Predicting RNA structures.

    Nature methods·2025
    Same author

    From blobology to atomic resolution.

    Nature methods·2024
    Same author

    A dynamic direction for cryo-EM.

    Nature methods·2022
    Same author

    Tracking protein conformation in live cells.

    Nature methods·2021
    Same author

    Graphene-on-gold grids for cryo-EM.

    Nature methods·2019
    Same author

    Probes for protein prenylation.

    Nature methods·2019
    Same journal

    ClairS: a deep-learning method for long-read tumor-normal pair somatic small variant calling.

    Nature methods·2026
    Same journal

    RNAbpFlow: base pair-augmented SE(3) flow matching for conditional RNA 3D structure generation.

    Nature methods·2026
    Same journal

    Spatio-DARLIN enables robust and efficient in situ lineage tracing in mice at single-cell resolution.

    Nature methods·2026
    Same journal

    EasyGrid: a versatile platform for automated cryo-EM sample preparation and quality control.

    Nature methods·2026
    Same journal

    Cloud-based microscope enables live neuroimaging for 24 h and beyond with worldwide access.

    Nature methods·2026
    Same journal

    Deep molecular profiling in three dimensions.

    Nature methods·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Structural Biology
    • Molecular Biology

    Background:

    • Protein crystallization is crucial for determining protein structure.
    • Current methods have limitations in crystallizing diverse proteins.
    • Expanding crystallization techniques is vital for structural biology advancements.

    Purpose of the Study:

    • To introduce novel, straightforward techniques for protein crystallization.
    • To enhance the scope of proteins amenable to structural analysis.
    • To facilitate broader application of protein crystallography.

    Main Methods:

    • Review of two recent reports detailing novel crystallization strategies.
    • Analysis of methodologies designed to overcome common crystallization challenges.

    Related Experiment Videos

  • Evaluation of the simplicity and applicability of the described methods.

    • Main Results:

    • The reported methods offer accessible approaches to protein crystallization.
    • These techniques have the potential to broaden the range of target proteins.
    • Successful application could streamline structural determination processes.

    Conclusions:

    • The described simple methods represent a significant advancement in protein crystallization.
    • These approaches may democratize protein structure determination.
    • Further research can validate and refine these techniques for wider use.