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Updated: Jul 18, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
Abstract:
A method is proposed to determine the efficacy of harmful agents, which is based on the assessment of a response of experimental animals by the mathematical-statistical methods formalizing the approaches accepted in hygienic toxicology. It makes it possible to introduce a more detailed classification of their efficacy in accordance with the respective rather strict criteria. This method unifies this procedure to a great extent, thus lowering the influence of subjective factors, which lets us correctly solve the task of establishing the hygienic regulations. The results of evaluation of the efficacy of two combinations of the concentrations of copper, iron, chromium, and zinc contained in the drinking water are given as an example.
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Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...

