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In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum
Fang Huang1, Lin-Hua Tang, Lin-Qian Yu
1National Institute of Parasite Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. huangfang78@yahoo.com.cn
Objective:
To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.
Method:
Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.
Results:
DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.
Conclusion:
Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.
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