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Updated: Jul 18, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica
Rabab Mohammed1, Jiangnan Peng, Michelle Kelly
1Department of Pharmacognosy, Pharmacology, Chemistry & Biochemistry and National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA.
Abstract:
Two new cyclic heptapeptides, stylisin 1(1) and stylisin 2 (2), were isolated and characterized from the Jamaican sponge Stylissa caribica, in addition to the cyclic heptapeptide phakellistatin 13 (3) and the known bromopyrrole alkaloids sceptrin (4), stevensine (5), and oroidin (6). The new structures were assigned on the basis of 1D and 2D NMR spectroscopic data, as well as chemical methods for the elucidation of the absolute configuration of amino acids. The peptides and alkaloids have been evaluated for their antimicrobial, antimalarial, anticancer, anti-HIV-1, anti-Mtb, and antiinflammatory activities.
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