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Updated: Jan 27, 2026

Behavioral Assays for Optogenetic Manipulation of Neural Circuits in Drosophila melanogaster
Published on: February 7, 2025
Retrograde control of neural circuit formation
Christopher D Deppmann1, David D Ginty
1The Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Abstract:
Glial-derived neurotrophic factor (GDNF), secreted by skeletal muscle, triggers expression of the ETS transcription factor Pea3 in a subset of motor neurons in the spinal cord. In this issue, find that this retrograde GDNF-Pea3 signal controls dendrite patterning and assembly of a sensory-motor reflex circuit.
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