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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

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Related Experiment Videos

Cutaneous sarcoidosis therapy updated.

Christy Badgwell1, Ted Rosen

  • 1Dermatology Department, Baylor College of Medicine, and Houston Veterans Affairs Medical Center, Texas, USA.

Journal of the American Academy of Dermatology
|December 28, 2006
PubMed
Summary

Standard treatments for cutaneous sarcoidosis include corticosteroids, antimalarials, and methotrexate. Newer targeted therapies are emerging due to a better understanding of the disease's immunopathogenesis.

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Cutaneous sarcoidosis is a complex inflammatory condition.
  • Standard treatments include corticosteroids, antimalarials, and methotrexate.
  • Disease progression is linked to specific immunopathogenic pathways.

Purpose of the Study:

  • To review current and emerging therapeutic strategies for cutaneous sarcoidosis.
  • To highlight the role of understanding disease mechanisms in developing new treatments.

Main Methods:

  • Literature review of established and novel treatments.
  • Analysis of immunopathogenic mechanisms underlying sarcoidosis.

Main Results:

  • Standard therapies remain a cornerstone of treatment.

Related Experiment Videos

  • Targeted therapies offer promising alternatives by addressing specific disease pathways.
  • Conclusions:

    • A deeper understanding of sarcoidosis immunopathogenesis is guiding the development of targeted therapies.
    • Future treatment strategies may involve a combination of standard and novel approaches for improved outcomes.