Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy
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Updated: Jul 18, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Maurizio A Leone1, Alessandra Solari, Ettore Beghi
1Clinica Neurologica, Ospedale Maggiore della Carità, C.so Mazzini, 18-28100 Novara, Italy. maurizio.leone@maggioreosp.novara.it
Abstract:
We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of epilepsy.
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