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Published on: May 15, 2019
Scleromyxedema: successful treatment with thalidomide in two patients
Mona Amini-Adle1, Nadege Thieulent, Stéphane Dalle
1Department of Dermatology, Hôpital de l'Hôtel Dieu, Lyon, France.
Background:
Scleromyxedema is an unusual skin disease characterized by mucinous infiltration of the skin. There is no satisfactory treatment for this disorder.
Case Report:
We report 2 cases of scleromyxedema, both associated with an IgG-lambda paraprotein. Treatment with thalidomide was started and great improvement of the lesion was noted as shown by a quality of life questionnaire similar to those used in rheumatoid arthritis. TNF-alpha value was elevated in both cases during this treatment.
Discussion:
We hypothesize that the efficiency of thalidomide could be mediated by its costimulatory effect on T cytotoxic lymphocytes.
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