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Updated: Jul 18, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
[Clinical application of medical grade calcium sulfate as a bone graft substitute]
Peng Liu1, Jianhua Zhao, Weili Fan
1Department of Orthopaedics, Daping Hospital and Institute of Field Surgery, Third Military Medical University, Chongqing, 400042, P R China.
Objective:
To investigate the clinical effect of medical grade calcium sulfate(Osteoset) as a bone graft substitute.
Methods:
From December 2004 to May 2005, 9 cases of bone defect(limb group) were repaired with Osteoset pellets; bone defect was caused by benign tumor in limbs, including 3 cases of fibroma xanthomas in humerus (1 case) and acetabulum (2 cases), 2 cases of bone cysts in humerus (1) and radius (1), 1 case of nonossifying fibroma, 1 case of ossifying fibroma and 2 cases of osteofibrous dysplasia in femurs. Five cases of lumbar posterolateral fusion (spine group) were treated with Osteoset pellets as autograft volume expander, including 2 cases of lumbar spinal stenosis, 2 cases of lumbar spondylolisthesis and 1 case of lumbar spondylolysis. Radiological method was used to evaluate the repair effect of Osteoset pellets.
Results:
The mean follow-up time was 6.2 months (3 to 9 months). Osteoset pellets began to be absorbed after 1 to 3 months of operation, and were totally absorbed and replaced by osseous tissue after 4 to 6 months. No local recurrence was detected in limb group and the function of limbs was normal. At 6 months after operation, all patients in spine group got bony fusion.
Conclusion:
Medical grade calcium sulfate (Osteoset) is an ideal bone graft substitute with excellent bone repair effect.
