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Updated: Jul 18, 2026

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
Published on: April 6, 2022
New photoproducts from irradiation of NADH with near-UV light
Ute Vitinius1, Kurt Schaffner, Martin Demuth
1Max-Planck-Institut für Bioanorganische Chemie (former MPI für Strahlenchemie), P.O. Box 101365, D-45413 Mülheim an der Ruhr. vitiniusu@yahoo.com
Abstract:
Adenosine 5'-diphosphoribose (ADPR) and a second compound, which may be nicotinamide, are the newly discovered photoproducts resulting from irradiation of beta-nicotinamide adenine dinucleotide (beta-NADH) in the wavelength range of 300-400 nm under oxygen-poor conditions. Both products emerge there even exclusively, whereas, at higher oxygen concentrations, the oxidized form of nicotinamide adenine dinucleotide (NAD+) is additionally formed, although still as a minor product. The development of ADPR and NAD+ is clearly oxygen-dependent, while, for the formation of the second photoproduct, small quantities of oxygen appear to be sufficient.
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