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Updated: Jul 18, 2026

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
Published on: August 12, 2019
Synthesis of encoded modified oligonucleotide libraries. Part 1: orthogonal chemistry
Paula A Sacca1, Angelo Fontana, Javier M Montserrat
1Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, CONICET-UBA, Vuelta de Obligado 2490, Buenos Aires, Argentina.
Abstract:
The basis for further development of combinatorial libraries of modified oligonucleotides tagged by a codifying sequence is discussed. The chemistry involved in the orthogonal synthesis of both strands and some representative examples of building blocks are presented.
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