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Activity and stability of hammerhead ribozymes containing 2'-C-methyluridine: a new RNA mimic

Mariana Gallo1, Rosel Kretschmer-Kazemi Far, Georg Sczakiel

  • 1Laboratorio NMR di biostrutture e biosistemi, Università degli studi di Roma Tor Vergata, Via della Ricerca Scientifica 1, I-00133 Rome. mariana.gallo@uniroma2.it

Chemistry & Biodiversity
|December 29, 2006
PubMed

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The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
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