Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A manzamine-derived compound as a potential therapeutic agent for glioma by inducing apoptosis and cell cycle arrest.

American journal of cancer research·2022
Same author

Acetylcholine esterase inhibitory activity of green synthesized nanosilver by naphthopyrones isolated from marine-derived Aspergillus niger.

PloS one·2021
Same author

Design and synthesis of β-carboline and combretastatin derivatives as anti-neutrophilic inflammatory agents.

Bioorganic chemistry·2021
Same author

Sesquiterpene Lactone Deoxyelephantopin Isolated from <i>Elephantopus scaber</i> and Its Derivative DETD-35 Suppress BRAF<sup>V600E</sup> Mutant Melanoma Lung Metastasis in Mice.

International journal of molecular sciences·2021
Same author

Macrophage Migration Inhibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline.

Scientific reports·2019
Same author

Cumingianoside A, a Phyto-Triterpenoid Saponin Inhibits Acquired BRAF Inhibitor Resistant Melanoma Growth via Programmed Cell Death.

Frontiers in pharmacology·2019

Related Experiment Video

Updated: Jul 18, 2026

HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis
07:29

HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis

Published on: November 11, 2022

New gemacranolides from Eupatorium hualienense.

Ya-Ching Shen1, Jiun-Yang Jang, Ashraf Taha Khalil

  • 1Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China.

Chemistry & Biodiversity
|December 29, 2006
PubMed
Summary

Researchers isolated five new eupahualins (A-E) and eupasimplicin B from Eupatorium hualienense. Compounds 1-4 and 6 demonstrated significant anti-cancer activity against leukemia and bone cancer cell lines.

More Related Videos

Automated HPLC Separation Using LC-Mate: An Integrated Repetitive Autosampler and Fraction Collector for Microscale Purification
07:11

Automated HPLC Separation Using LC-Mate: An Integrated Repetitive Autosampler and Fraction Collector for Microscale Purification

Published on: February 27, 2026

Related Experiment Videos

Last Updated: Jul 18, 2026

HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis
07:29

HPLC Coupled with Chemical Fingerprinting for Multi-Pattern Recognition for Identifying the Authenticity of Clematidis Armandii Caulis

Published on: November 11, 2022

Automated HPLC Separation Using LC-Mate: An Integrated Repetitive Autosampler and Fraction Collector for Microscale Purification
07:11

Automated HPLC Separation Using LC-Mate: An Integrated Repetitive Autosampler and Fraction Collector for Microscale Purification

Published on: February 27, 2026

Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Eupatorium hualienense is a plant species with potential medicinal properties.
  • Sesquiterpene lactones are a class of natural products known for diverse biological activities.

Purpose of the Study:

  • To conduct a phytochemical investigation of Eupatorium hualienense.
  • To isolate and characterize new compounds from the plant.
  • To evaluate the cytotoxic activity of isolated compounds against cancer cell lines.

Main Methods:

  • Phytochemical isolation techniques.
  • Structure elucidation using comprehensive spectral analyses, including 2D-NMR.
  • In vitro cytotoxic assays against K562 (human chronic myelogenous leukemia) and U2OS (human bone cancer) cell lines.

Main Results:

  • Isolation of five new sesquiterpene lactones, eupahualins A-E (1-5).
  • Identification of the known heliangolide eupasimplicin B (6).
  • Compounds 1-4 and 6 exhibited significant cytotoxic activities against K562 and U2OS cell lines.

Conclusions:

  • Eupatorium hualienense is a source of novel sesquiterpene lactones with potential anti-cancer properties.
  • Eupahualins A-E and eupasimplicin B represent promising leads for further investigation in cancer therapy.
  • The study highlights the importance of natural products in drug discovery for leukemia and bone cancer.