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Updated: Jul 18, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
Published on: August 12, 2019
One-pot procedure for diazo transfer and azide-alkyne cycloaddition: triazole linkages from amines
Henning S G Beckmann1, Valentin Wittmann
1Fachbereich Chemie, Universität Konstanz, D-78457 Konstanz, Germany.
Abstract:
[reaction: see text] A one-pot reaction for Cu(II)-catalyzed diazo transfer and Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (sometimes called click reaction) is reported. 1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields from a variety of readily available amines without the need for isolation of the azide intermediates. The reaction has a broad scope and is especially practical for the synthesis of multivalent structures because compounds substituted with multiple azides are potentially unstable.
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