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Updated: Jul 18, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
Published on: February 1, 2018
Synthesis of beta-lactam scaffolds for ditopic peptidomimetics
Claudio Palomo1, Jesus M Aizpurua, Eva Balentova
1Departamento de Química OrgAnica-I, Universidad del País Vasco, Facultad de Química, Apdo 1072, 20080 San SebastiAn, Spain.
Abstract:
[reaction: see text] Ring opening of alpha-substituted-alpha-methoxycarbonyl-N-nosylaziridines provides a practical access to enantiopure alpha,alpha'-disubstituted beta-lactam scaffolds, novel types of ditopic reverse turn surrogates. The procedure is general, short, and high yielding and starts from handy alpha-substituted serinates and alpha-amino acid derivatives.
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