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Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury

Ilya Sabsovich1, Zia Rehman, Jose Yunen

  • 1Surgical and Trauma Intensive Care Unit, Elmhurst Hospital Center, Mount Sinai School of Medicine, New York, NY, USA.

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses
|December 29, 2006
PubMed

Insights

Propofol infusion syndrome is a rare, fatal complication in critically ill children. Early recognition of metabolic acidosis and rhabdomyolysis is crucial for managing this severe condition.

Area of Science:

  • Intensive Care Medicine
  • Pediatric Critical Care
  • Pharmacology

Background:

  • Propofol is commonly used for sedation in critically ill pediatric patients.
  • Prolonged, high-dose infusions of propofol can lead to serious adverse events.
  • Understanding rare complications is vital for patient safety.

Observation:

  • A 16-year-old boy with severe traumatic brain injury developed metabolic acidosis and rhabdomyolysis during propofol infusion.
  • The patient progressed to acute renal failure, cardiac dysrhythmia, and circulatory collapse.
  • These clinical signs are consistent with Propofol Infusion Syndrome (PRIS).

Findings:

  • Propofol Infusion Syndrome (PRIS) is characterized by metabolic acidosis, rhabdomyolysis, and cardiac failure.
  • The syndrome can be fatal, even in previously healthy individuals.
  • Despite awareness, PRIS remains underdiagnosed.

Implications:

  • Increased vigilance is needed for early detection of PRIS in pediatric patients receiving propofol.
  • Prompt management of metabolic acidosis and supportive care are critical.
  • Further research into PRIS pathophysiology and treatment is warranted.

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