Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acetyl- and butyrylcholinesterase activities decrease in human colon adenocarcinoma.

María Fernanda Montenegro1, Francisco Ruiz-Espejo, Francisco Javier Campoy

  • 1Departamento de Bioquímica y Biología Molecular-A, Universidad de Murcia, 30071 Murcia, Spain.

Journal of Molecular Neuroscience : MN
|December 29, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations Between Nasal Receptors and Olfactory Dysfunction and Dysgeusia in Coronavirus Disease 2019 (COVID-19).

Journal of clinical medicine·2026
Same author

Functional characterization of splice variants in hereditary breast and ovarian cancer susceptibility genes.

Familial cancer·2025
Same author

Subcutaneous Injection of Human Colorectal Cancer Cells in Athymic Nude Mice to Evaluate Antitumor Efficacy.

Journal of visualized experiments : JoVE·2025
Same author

Ex vivo engineering of phagocytic signals in breast cancer cells for a whole tumor cell-based vaccine.

BMC cancer·2025
Same author

Recurrent genetic variants and prioritization of variants of uncertain clinical significance associated with hereditary breast and ovarian cancer in families from the Region of Murcia.

Advances in laboratory medicine·2023
Same author

Advances in laboratory medicine·2023

This study investigated cholinesterase (ChE) activity in gut carcinomas. Findings indicate altered ChE activity in these tumors, suggesting a role in cancer development.

Area of Science:

  • Biochemistry
  • Oncology
  • Neuroscience

Background:

  • Cholinesterases (ChEs), including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), are enzymes involved in acetylcholine hydrolysis.
  • Beyond catalysis, ChEs play non-catalytic roles in crucial biological processes like hematopoiesis, morphogenesis, and neurogenesis.
  • ChE involvement in tumorigenesis is suggested by gene amplification in leukemias and ovarian tumors, and correlations with astrocytoma aggressiveness.

Purpose of the Study:

  • To investigate potential alterations in cholinesterase (ChE) activity within gut carcinomas.
  • To explore the role of ChE in the context of gastrointestinal cancer.

Main Methods:

  • Measurement of cholinesterase (ChE) activity in gut carcinoma samples.
  • Analysis of ChE activity levels compared to non-cancerous tissues (implied).

Related Experiment Videos

Main Results:

  • Cholinesterase (ChE) activity was found to be altered in gut carcinomas.
  • Specific patterns of ChE alteration in these tumors were observed (details not provided in abstract).

Conclusions:

  • Altered cholinesterase (ChE) activity is a feature of gut carcinomas.
  • These findings suggest a potential role for ChEs in the development or progression of gastrointestinal cancers.