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Genetic association study on colony-stimulating factor 1 in Alzheimer's disease

M Axel Wollmer1, Roger M Nitsch, Christoph Hock

  • 1Division of Psychiatry Research, University of Zurich, Zurich, Switzerland. awollmer@bli.unizh.ch

Neuro-Degenerative Diseases
|December 29, 2006
PubMed
Abstract

Insights

Genetic variations in the Colony-stimulating factor 1 (CSF1) gene do not appear to increase Alzheimer's disease (AD) risk. This study found no association between CSF1 single nucleotide polymorphisms and AD susceptibility.

Area of Science:

  • Neuroscience
  • Genetics
  • Immunology

Background:

  • Colony-stimulating factor 1 (CSF1) is crucial for microglial cell development and function.
  • CSF1 deficiency in mice leads to neurodevelopmental issues and increased neuronal vulnerability.
  • The CSF1 gene's location on chromosome 1p21-p13, a region associated with Alzheimer's disease (AD), suggests CSF1 as a potential candidate gene for AD.

Purpose of the Study:

  • To investigate whether genetic variations within the CSF1 gene influence the risk of developing Alzheimer's disease (AD).

Main Methods:

  • A population-based case-control association study was performed.
  • Three single nucleotide polymorphisms (SNPs) across the CSF1 locus were analyzed.
  • The study included a total of 512 individuals (185 for rs3093054 and rs756325, 327 for rs1058885).

Main Results:

  • No statistically significant association was found between the three investigated CSF1 SNPs and the risk of Alzheimer's disease (AD).

Conclusions:

  • The findings do not support the hypothesis that genetic variability in the CSF1 gene contributes to Alzheimer's disease (AD) risk.
  • Further research may be needed to explore other genetic or environmental factors in AD pathogenesis.

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