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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Jul 18, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Clear cell sarcoma of soft tissues.

Sara Sofia Malchau1, James Hayden, Francis Hornicek

  • 1Orthopaedic Oncology Service, Massachusetts General Hospital, Boston, Massachusetts, USA.

Journal of Surgical Oncology
|December 29, 2006
PubMed
Summary

Clear cell sarcoma (CCS) is a rare, malignant soft tissue tumor. Despite aggressive treatment, it shows high recurrence and metastasis rates, emphasizing the need for prompt, wide surgical intervention and adjuvant therapy.

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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

  • Oncology
  • Surgical Pathology
  • Soft Tissue Tumors

Background:

  • Clear cell sarcoma (CCS) is a rare, highly malignant soft tissue tumor.
  • Typically presents as a small, tender mass in the deep tissues of the distal extremities.

Purpose of the Study:

  • To highlight the aggressive nature of clear cell sarcoma.
  • To emphasize the risks associated with treating this tumor.
  • To advocate for aggressive treatment strategies.

Main Methods:

  • Retrospective study of 17 patients with clear cell sarcoma treated since 1986.
  • Analysis of treatment outcomes including local recurrence, metastasis, and survival rates.

Main Results:

  • High incidence of local recurrence and metastasis observed.
  • Survival rate of only 47% despite surgery and adjuvant therapy.
  • Indicates a poor prognosis for clear cell sarcoma.

Conclusions:

  • Clear cell sarcoma poses significant treatment challenges.
  • Wide surgical excision is crucial for managing this malignancy.
  • Adjuvant therapy should be utilized to improve patient outcomes.