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Updated: Jul 18, 2026

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
'Green' synthesis of nitro alcohols catalyzed by solid-supported tributylammonium chloride in aqueous medium
Zongting Wang1, Huiqing Xue, Shuchao Wang
1School of Chemistry & Chemical Engineering, Chinese University of Petroleum, Dongying, 257062, PR China. ztiwang@hdpu.edu.cn
Abstract:
A series of 1-aryl-2-nitroalkan-1-ols (5a-m; Table 2) was prepared in yields of 64-94% by Henry reaction between aromatic aldehydes and nitroalkanes in the presence of a dual catalytic system of KOH and polystyrene-supported tributylammonium chloride (PsTBAC; 2). The reactions were performed either in H2O containing 10% of THF or, in the case of liquid reagents (aldehydes and nitroalkanes), in neat H2O at room temperature. The immobilized phase-transfer catalyst, designed to be used for large-scale industrial processes, could be easily separated from the products, and effectively re-used several times, basically without loss in activity.
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