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Published on: August 16, 2018
Trichotomoside: a new antioxidative phenylpropanoid glycoside from Clerodendron trichotomum
Sungwook Chae1, Kyoung Ah Kang, Ju Sun Kim
1Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
Abstract:
The structure and antioxidant properties of a new natural glycoside, trichotomoside (1), isolated from Clerodendron trichotomum, were investigated. Trichotomoside was identified as 2-(3-hydroxy-4-methoxyphenyl)ethyl 3-O-(2,3-di-O-acetyl-alpha-L-rhamnopyranosyl)-4-O-[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside. The compound was active towards intracellular reactive oxygen species (ROS) and exhibited DPPH-radical-scavenging effects. The radical-scavenging activity of 1 was found to protect the viability of Chinese hamster lung fibroblasts (V79-4 cells) exposed to H2O2 and gamma-irradiation.
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