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Updated: Jul 18, 2026

Oral Gavage in Neonatal Mouse Pups and Functional Assessment of Gut Barrier Integrity Using Ussing Chambers
Published on: January 9, 2026
[Upper gastrointestinal endoscopy in neonates--experience of pediatric gastroenterology unit]
Sonia Mazigh M'rad1, Sami Boukthir, Khaoula Aissa
1Service de Mèdecine Infantile C, Hôpital d'Enfants de Tunis.
Unlabelled:
The aim of our study was to assess the frequency of the different lesions occurring as well as to precise indications of upper gastrointestinal endoscopy in neonates.
Method:
We have achieved a retrospective study about 128 neonatal gastrointestinal endoscopies. Three groups were constituted according to macroscopic findings: Group I: normal aspect (n=11); Group II: isolated esophagitis (n=19); Group III: esogastritis or gastroduodenitis or esogastroduodenitis (n=92).
Results:
The neonates undergoing endoscopy for malaise were more frequent in group I than in group II and III, respectively 36.5% versus 15.8% and 9.8% (P = 0.04). Digestive hemorrhage (hematemesis and/or melena) was more frequent in group III than in group II and I, respectively 90.2% versus 78.9% and 63.6% (P = 0.03). Digestive hemorrhage was in our study the main indication of upper gastrointestinal endoscopy in neonates (85.9%) which showed a macroscopic lesion in 93.5% of cases.
Conclusion:
Hematemesis and suspicion of esophagitis are good indications for upper gastrointestinal endoscopy in neonates.
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