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A new Bacillus pasteurii urease inhibitor from Euphorbia decipiens
Muhammad Arif Lodhi1, Javid Hussain, Muhammad Athar Abbasi
1Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Journal of Enzyme Inhibition and Medicinal Chemistry
|December 30, 2006
Abstract:
Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. and Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 +/- 0.7 microM.
