Related Experiment Video
Updated: Jul 18, 2026
08:33
Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Drug-induced musculoskeletal disorders
1Division of Therapeutics, Victor Segalen University & Department of Rheumatology, University Hospital of Bordeaux, Bordeaux, France. bernard.bannwarth@u-bordeaux2.fr
Drug Safety
|December 30, 2006
Summary
Medications can cause a wide range of musculoskeletal disorders, from mild joint pain to severe conditions. Recognizing drug-induced rheumatic symptoms is key for accurate diagnosis and patient management.
Area of Science:
- Rheumatology
- Pharmacology
- Musculoskeletal Medicine
Background:
- Drug-induced musculoskeletal disorders encompass a spectrum from asymptomatic changes to severe, life-threatening conditions.
- An increasing number of medications are linked to rheumatic symptoms, necessitating awareness among clinicians.
Purpose of the Study:
- To provide an overview of common drug-induced musculoskeletal disorders.
- To highlight key drug classes associated with these conditions.
Main Methods:
- Review of literature on drug-induced musculoskeletal disorders.
- Categorization of disorders including arthralgias, connective tissue diseases, periarticular disorders, bone diseases, and myopathies.
Main Results:
- Commonly implicated drug classes include corticosteroids, vaccines, antibacterials, and lipid-lowering agents.
- Disorders range from arthralgias and inflammatory arthritis to osteoporosis and myopathies.
Conclusions:
- Clinicians should consider medication as a potential cause for musculoskeletal disorders.
- Early identification and discontinuation of the offending agent, alongside appropriate monitoring and preventive actions, are crucial for patient management.
Related Concept Videos
01:28Disorders of the Skeletal Muscle
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
01:21Skeletal Muscle Relaxants: Adverse Effects
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
01:31Skeletal Muscle Relaxants: Therapeutic Uses
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:26Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
01:28Classification of Skeletal Muscle Relaxants
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...