Related Experiment Video
Updated: Jul 18, 2026
07:46
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
Published on: June 4, 2012
Case report: infective endocarditis caused by Brevundimonas vesicularis
Mei-Li Yang1, Yen-Hsu Chen, Tun-Chieh Chen
1Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. 940424@ms.kmuh.org.tw
BMC Infectious Diseases
|December 30, 2006
Summary
This case study highlights Brevundimonas vesicularis as a rare cause of infective endocarditis in an otherwise healthy individual. Effective treatments included ceftriaxone and ciprofloxacin, with ampicillin/sulbactam showing limited efficacy.
Area of Science:
- Infectious Diseases
- Bacteriology
- Cardiology
Background:
- Invasive infections by Brevundimonas vesicularis are rarely reported, especially in immunocompetent individuals.
- Limited data exists on optimal antimicrobial therapy for Brevundimonas vesicularis bacteremia.
Observation:
- A case of subacute infective endocarditis in a 40-year-old healthy male is presented.
- The endocarditis was attributed to an occult dental abscess and caused by Brevundimonas vesicularis, confirmed by blood cultures.
Findings:
- The patient successfully recovered without complications following treatment with ceftriaxone and ciprofloxacin.
- Ampicillin/sulbactam treatment failed, and ceftriaxone was discontinued due to an allergic reaction.
Implications:
- This is the first reported case of Brevundimonas vesicularis causing infective endocarditis.
- Third-generation cephalosporins, piperacillin/tazobactam, and ciprofloxacin are suggested as effective treatments for invasive Brevundimonas vesicularis infections.
- Further evaluation is needed for the efficacy of ampicillin/sulbactam against this pathogen.
Related Concept Videos
01:25Endocarditis I: Introduction
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
01:18Endocarditis III: Medical Management
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
01:29Endocarditis IV: Nursing Management
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
01:24Bacterial Meningitis
Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
01:26Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...