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Development of the Heart

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

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Related Experiment Video

Updated: Jul 18, 2026

An Apical Resection Model in the Adult Xenopus tropicalis Heart

An Apical Resection Model in the Adult Xenopus tropicalis Heart

Published on: November 18, 2022

Xenopus as a model system for vertebrate heart development.

Andrew S Warkman¹, Paul A Krieg

¹Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, 1501 N. Campbell Avenue, P.O. Box 245044, Tucson, AZ 85724, USA. awarkman@email.arizona.edu

Seminars in Cell & Developmental Biology

|December 30, 2006

Summary

The African clawed frog (Xenopus laevis) is a key model for studying vertebrate heart development. Research utilizes its embryology, molecular tools, and genomics to uncover conserved genetic mechanisms.

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Area of Science:

Developmental Biology
Comparative Genomics
Cardiovascular Research

Background:

The African clawed frog (Xenopus laevis) serves as a crucial model organism for understanding vertebrate heart development.
Established embryological and molecular techniques facilitate research in Xenopus.

Purpose of the Study:

To review methodologies and key discoveries in Xenopus-based heart development research.
To highlight the utility of the Xenopus tropicalis genome sequence for genetic and regulatory element identification.
To discuss the application of forward and reverse genetics in studying cardiac development.

Main Methods:

Embryological techniques
Molecular biology methodologies
Genome sequencing and analysis
Forward and reverse genetics

Main Results:

Xenopus research has yielded significant insights into vertebrate heart development.
The Xenopus tropicalis genome aids in identifying orthologous genes and conserved regulatory elements.
Genetic approaches are advancing the study of cardiac development mechanisms.

Conclusions:

Xenopus laevis is an indispensable model for dissecting vertebrate heart development.
Genomic resources and genetic tools in Xenopus accelerate discoveries in cardiovascular research.
Continued application of these methods promises further breakthroughs in understanding heart formation.