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Xenopus as a model system for vertebrate heart development

Andrew S Warkman1, Paul A Krieg

  • 1Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, 1501 N. Campbell Avenue, P.O. Box 245044, Tucson, AZ 85724, USA. awarkman@email.arizona.edu

Seminars in Cell & Developmental Biology
|December 30, 2006
PubMed

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...