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Human papillomavirus detection in urine samples: an alternative screening method
Francesc Alameda1, Beatriz Bellosillo, Pere Fusté
1Department of Pathology, University Hospital del Mar, Autonomous University of Barcelona, Barcelona, Catalonia, Spain. 86780@imas.imim.es
Objectives:
To investigate the usefulness of human papillomavirus detection in the urine of women with poor gynecologic attention.
Materials And Methods:
Fifty urine and 50 cervical samples from 50 women were analyzed. Polymerase chain reaction was performed on these 100 samples using consensus primers and a low-density microarray-based method for human papillomavirus typing.
Results:
The concordance of the results between both sample groups was 80%. In the urine samples, the sensitivity of polymerase chain reaction for high-grade squamous intraepithelial lesion was 100%, the specificity was 80%, the positive predictive value was 91%, and the negative predictive value was 100%.
Conclusions:
Human papillomavirus detection in urine samples may be used as an alternative screening method for women with poor gynecologic attention.
