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[Drug binding to blood proteins: characteristics, roles and pathophysiological changes]

Jean-Paul Tillement1, Jean-Claude Duché, Jérôme Barré

  • 1Unité Fonctionnelle de Pharmacologie et Toxicologie, CHIC, 40 Avenue de Verdun, F-94010 Creteil. jpmtillement@hotmail.com

Bulletin De L'Academie Nationale De Medecine
|January 2, 2007
PubMed
Summary

Human serum albumin (HSA) and alpha-1-acid glycoprotein (AGP) are key plasma proteins that bind drugs. This restrictive binding impacts drug distribution and elimination, influencing pharmacokinetic parameters and clinical outcomes.

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