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10:28
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
[Autochthonous hepatitis E in France]
Yves Buisson1, Elisabeth Nicand
1Institut de Mèdecine tropicale du Service de santé des armées, B.P. 46, 13998 Marseile Armées.
Bulletin De L'Academie Nationale De Medecine
|January 2, 2007
Summary
Hepatitis E is now found in France, not just imported. New tests will improve diagnosis, and a national surveillance program is needed due to its risks, especially in pregnancy.
Area of Science:
- Hepatology
- Virology
- Public Health
Context:
- Hepatitis E is increasingly recognized as a domestically acquired infection in non-endemic regions.
- Autochthonous (locally acquired) Hepatitis E cases are confirmed in France.
- Existing diagnostic protocols for acute hepatitis may not adequately account for non-travel-related Hepatitis E.
Purpose:
- To emphasize the presence of autochthonous Hepatitis E in France.
- To advocate for the inclusion of Hepatitis E diagnostic markers in routine etiological workups for acute hepatitis.
- To highlight the need for enhanced surveillance and diagnostic capabilities for Hepatitis E.
Summary:
- Hepatitis E is no longer solely an imported disease; it is endemic in France.
- Biological markers for Hepatitis E should be integrated into diagnostic algorithms for acute hepatitis, irrespective of travel history.
- Development of more sensitive serological assays based on recombinant viral capsid protein is anticipated.
- The severity of Hepatitis E, particularly in pregnant women, necessitates a national surveillance program.
- This program should assess the animal reservoir and risks from food and waterborne transmission.
Impact:
- Improved clinical recognition and diagnosis of Hepatitis E in France.
- Enhanced public health strategies to control Hepatitis E transmission.
- Reduced morbidity and mortality associated with Hepatitis E, especially in vulnerable populations like pregnant women.
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