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Published on: November 5, 2019
Psychiatric adjustment in the year after meningococcal disease in childhood
Daniel Shears1, Simon Nadel1, Julia Gledhill1
1Drs. Shears, Gledhill, and Garralda are with the Imperial College London, Academic Unit of Child and Adolescent Psychiatry; Dr. Nadel is with the St. Mary's Hospital, London; and Dr. Gordon is with the Imperial College London, Statistical Advisory Service.
Insights
Psychiatric disorders are common in children following meningococcal disease, with over half experiencing issues in the year after illness. Severe illness and pre-existing behavioral problems increase this risk.
Area of Science:
- Pediatric infectious diseases
- Child and adolescent psychiatry
- Neuropsychology
Background:
- Meningococcal disease can have significant long-term health consequences.
- The psychiatric impact of meningococcal disease in children requires further investigation.
Purpose of the Study:
- To evaluate the psychiatric status of children after experiencing meningococcal disease.
- To identify risk factors associated with developing psychiatric disorders post-illness.
Main Methods:
- A cohort study involving 66 children (ages 4-17) admitted for meningococcal disease.
- Psychiatric disorders were assessed using standardized interviews and questionnaires at 1-year follow-up.
Main Results:
- 57% of children aged 6+ experienced psychiatric disorders within a year of discharge.
- Common disorders included depression, oppositional defiant disorder, and anxiety.
- Illness severity, shock on admission, and premorbid behavioral issues predicted later psychiatric conditions.
Conclusions:
- Psychiatric disorders are a frequent outcome in the year following meningococcal disease in children.
- Children with severe meningococcal illness and pre-existing emotional/behavioral problems are at higher risk.
Objective:
To assess psychiatric status after meningococcal disease.
Method:
Cohort study of 66 children (34 boys, 32 girls) ages 4 to 17 years admitted to pediatric hospitals with meningococcal disease. The main outcome measure was psychiatric disorder (1-year period and point prevalence on the Schedule for Affective Disorders and Schizophrenia for School-Age Children interview for children 6 years or older; point prevalence in younger children on the Behavior Screening Questionnaire).
Results:
During the course of the year after discharge from hospital, psychiatric disorders were identified in 23 of 40 (57%) children ages 6 years or older. The most common primary disorders were depressive, oppositional defiant, and anxiety disorders. At the time of 12-month follow-up, psychiatric disorders were present in 13 of 40 (32%) of those ages 6 or older and in 7 of 26 (26%) under 6 years old. Two children had a diagnosis of posttraumatic stress disorder. Logistic regression analysis showed that global meningococcal illness severity score, clinical shock on admission, and impairing premorbid emotional and behavioral problems in the child were independent predictors of psychiatric disorder at 12-month follow-up.
Conclusions:
Psychiatric disorders are common in the year after meningococcal disease. Especially at risk are children who are severely medically ill and those with more impairing premorbid emotional and behavioral problems.
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