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Updated: Jul 18, 2026

Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Update on gingival overgrowth by cyclosporine A in renal transplants
Domenico Ciavarella1, Rosario Guiglia, Giuseppina Campisi
1Department of Surgical Sciences, University of Foggia, Foggia, Italy.
Abstract:
Severe gingival overgrowth is one of the most frequent side effects in renal transplant patients associated with assumption of cyclosporine A. Several associations with age, sex, dosage, duration of therapy or interval since transplantation have been hypothesized. The introduction of alternative immunosuppressant drugs have been suggested to permit better long-term transplant outcomes and a decrease in incidence of gingival overgrowth. The aim of the present paper is to summarize current knowledge regarding aetiology, pathogenesis and management of gingival overgrowth induced by Cyclosporine A.
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Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
