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Published on: August 22, 2014
Premorbid exercising in specific cognitive tasks prevents impairment of performance in parkinsonian monkeys
Sebastián J Lipina1, Jorge A Colombo
1Unidad de Neurobiología Aplicada (UNA) (CEMIC), Av. Galván 4102 C1431FWO, Buenos Aires, Argentina.
Abstract:
Adult Cebus apella monkeys were exposed to either one, two or four series of cognitive tasks that place a demand on working memory and inhibitory control (Spatial Delayed Response and Object Retrieval Detour), before administration of the neurotoxin 1-methyl-1-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Following MPTP treatment, monkeys receiving more than one series successfully reached criteria at delays similar to those attained during the pre-MPTP stage for the Spatial Delayed Response task and avoided increased perseveration in the Object Retrieval Detour task. Results provide evidence that protection towards a neurotoxin in specific cognitive performances can be increased by repeated exposure to task-specific cognitive demands and that motor and cognitive impairment following MPTP treatment can be effectively dissociated in primates.
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