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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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Diphenyl ditelluride effect on embryo/fetal development in mice: interspecies differences.

Silvane Souza Roman1, Alexandra Nava, Alexandre Marafon Favero

  • 1Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105-900, Santa Maria, RS, Brazil.

Toxicology
|January 2, 2007
PubMed
Summary

Diphenyl ditelluride, (PhTe)(2), shows lower developmental toxicity in mice than in rats. Mice required a significantly higher dose of (PhTe)(2) to exhibit adverse embryo/fetal effects, indicating species-specific susceptibility.

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Area of Science:

  • Toxicology
  • Developmental Biology
  • Comparative Toxicology

Background:

  • Diphenyl ditelluride ((PhTe)(2)) is a known teratogen in rats.
  • Limited data exists on (PhTe)(2)'s effects on mouse embryo/fetal development.
  • Investigating interspecies differences in (PhTe)(2) developmental toxicity is crucial.

Purpose of the Study:

  • To compare the effects of diphenyl ditelluride ((PhTe)(2)) on mouse embryo/fetal development across different gestational periods.
  • To assess potential species-specific differences in susceptibility to (PhTe)(2) toxicity compared to rats.

Main Methods:

  • Pregnant mice were administered subcutaneous injections of 0.12 or 60.0 mg/kg (PhTe)(2) on gestational days (GD) 4, 8, or 14.
  • Cesarean sections were performed on GD18 to examine external and skeletal fetal alterations.
  • Maternal organ weights (liver, spleen, kidney) and body weight were also recorded.

Main Results:

  • The lower dose of (PhTe)(2) had no adverse effects on mouse fetuses.
  • Maternal liver, spleen, and kidney weights increased at specific gestational days with the higher dose.
  • Reduced implantation sites, fetal weight, biometry, and minor ossification defects were observed at GD4 and GD14 with the higher dose.
  • Mice showed reduced susceptibility to (PhTe)(2) toxicity compared to rats, requiring approximately 500-fold higher doses.

Conclusions:

  • Diphenyl ditelluride ((PhTe)(2)) is significantly less toxic to mouse dams and embryos/fetuses compared to rats.
  • Gestational exposure to (PhTe)(2) in mice at high doses can impact fetal development, but with less severity than in rats.
  • These findings highlight significant interspecies differences in the developmental toxicity of (PhTe)(2).