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Updated: May 6, 2026
07:07
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
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Teeth: malignant neoplasms in the dental pulp?
1Clinic for Periodontology, Endodontology, and Cariology, School of Dentistry, University of Basle, Hebelstrasse 3, CH-4056 Basel, Switzerland. Klaus.Neuhaus@unibas.ch
The Lancet. Oncology
|January 2, 2007
Summary
Primary malignant neoplasms of the dental pulp are rare. Historical literature suggests pulpal tumors may exist, potentially leading to pulpitis and requiring root canal treatment or extraction.
Area of Science:
- Dentistry
- Oral Pathology
- Oncology
Background:
- Dental pulp pathologies are typically inflammatory, caused by caries or trauma.
- Neoplastic alterations of the dental pulp are generally considered non-existent in current literature.
- PubMed searches for primary malignant neoplasms of the dental pulp yield no reports.
Purpose of the Study:
- To investigate historical reports of dental pulp tumors.
- To explore the pathogenesis of pulpal neoplasms considering dental pulp anatomy.
- To hypothesize the clinical presentation and management of dental pulp tumors.
Main Methods:
- Hand search of historic published literature for pulpal tumors.
- Deductive reasoning on general tumor pathogenesis applied to dental pulp anatomy.
- Literature review of neoplastic alterations and dental pulp pathologies.
Main Results:
- Historical clinical reports of pulpal tumors were identified.
- Tumor expansion within the tooth's restricted space may cause secondary dentine formation and pulp infarction.
- A hypothesis suggests pulpal neoplasms may present as chronic appositive pulpitis.
Conclusions:
- Primary malignant neoplasms of the dental pulp are exceptionally rare, though historical reports suggest their existence.
- The unique anatomy of the dental pulp influences tumor behavior, potentially leading to irritation dentine and hemorrhage.
- Further research, including stem-cell studies, is recommended to elucidate the nature of dental pulp neoplasms.
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